Curr Biol：分散注意力可有效消除疼痛感

近日，发表文章在International著名杂志Cell的子刊Current Biology上的一篇科学研究报告指显露，利用人格妨碍（自觉）的作法可以使得呕吐减低，然而这种呕吐缓解减低的现像并不表现在头部。这项科学研究注意到是基于用作高分辨率的肝脏机能性磁共振成像关键技术（fMRI关键技术），对人们由于高温造成的呕吐技术水平开展科学研究，科学研究揭示，人格妨碍显然可以在中枢呕吐管控早期抑制呕吐信号的传入。来自吕贝克-埃彭岑大学医学院的科学人类学家Christian Sprenger说明，这种现象并不仅仅是一种人格现象，而是一种活跃的神经机制，可以提高从脑部上升至大脑高级周边的呕吐信号。

这种现像涉及到了内源性的类物质，这种物质产生自大脑，在减低呕吐的过程中扮演着极其重要片中。科学研究人员让与会者分别完成一个简单或者一个都能的记忆性特殊任务，需要他们记住电子邮件的注释内容，同时给与会者胳膊上施以高温。开展都能特殊任务的与会者愈发心烦意乱时，他们会感到较少的呕吐，通过fMRI关键技术体现显露这些与会者的脑部周边活性愈发比较高于，fMRI通常是用来测定大脑活性的改变。

Sprenger和他的上司然后反复了测试，这次他们给予与会者一种本品-钠洛酮（抗休克的理想本品，可以阻挡唑的现像）或者除此以外的湾里注入，%-，比起只注入除此以外湾里的与会者，用作唑特异性的与会者由于注意力分散，造成的呕吐缓解提高了40%，因此断定内源性的扮演着极其重要功用。

科学人类学家的注意到揭示了人格过程可以集中地改变人们的呕吐经历，并且对于临床也有极其极其重要的意义。科学人类学家说明，我们的科学研究注意到给呕吐疾病病人包括了认知行为病人的作法。（生物谷：T.Shen编译器）

doi:10.1016/j.cub.2012.04.006PMC:PMID:

Attention Modulates Spinal Cord Responses to Pain

Christian Sprenger1, , , Falk Eippert1, Jürgen Finsterbusch1, Ulrike Bingel1, 2, Michael Rose1, Christian Büchel1

Reduced pain perception while being distracted from pain is an everyday example of how cognitive processes can interfere with pain perception [ [1], [2], [3], [4] and [5]]. Previous neuroimaging studies showed distraction-related modulations of pain-driven activations in various cortical and subcortical brain regions [ [6], [7], [8], [9], [10] and [11]], but the precise neuronal mechanism underlying this phenomenon is unclear. Using high-resolution functional magnetic resonance imaging of the human cervical spinal cord in combination with thermal pain stimulation and a well-established working memory task [12], we demonstrate that this phenomenon relies on an inhibition of incoming pain signals in the spinal cord. Neuronal responses to painful stimulation in the dorsal horn of the corresponding spinal segment were significantly reduced under high working memory load compared to low working memory load. At the individual level, reductions of neuronal responses in the spinal cord predicted behioral pain reductions. In a subsequent behioral experiment, using the opioid antagonist naloxone in a double-blind crossover design with the same paradigm, we demonstrate a substantial contribution of endogenous opioids to this mechanism. Taken together, our results show that the reduced pain experience during mental distraction is related to a spinal process and involves opioid neurotransmission.